Neurolac 

Neurolac® nerve guides facilitate nerve regeneration after transsection of peripheral nerves and improve nerve function recovery. 

It is made of a 100% synthetic lactide-caprolactone polymeric material. Mechanical support is given to the healing nerve for a period of 12 weeks. 

The Neurolac nerve guide has been clinically evaluated in a randomized multicenter study comparing it with end-to-end repair and autologous grafting

 

Advantages of Neurolac:

  • Improved nerve-function recovery and less adverse side effects

  • High transparency to enable simple surgical procedures

  • Significant reduction of operation time

  • No need for harvesting autologous nerve grafts

  • No donor site morbidity and loss of sensation at the donor site

  • Fully synthetic material, hence microbiological safe and non-immunogenic

  • Broad range (diameter and length) of nerve guide sizes available 
     

Function:
  • Actively directs axons sprouting from the proximal nerve ends towards the distal nerve stump
  • Prevents neuroma formation and intervention of fibrous material at the wound surface
  • The nerve guide keeps neurite-promoting factors, neurotrophic substances and cell adhesion molecules that are released by the injured nerve tissue contained near the junction 
     

Materials: 
  • Neurolac is produced of p0ly(DL-lactide-e-caprolactone), a synthetic bio-degradable polyester
  • Tubes are flexible with sufficient mechanical strength and kinking resistance to withstand pressure forces 

 


 

Degradation:
  • Poly(DL-lactide-e-caprolactone) material holds its mechanical properties up to 10-12 weeks.
  • It degrades mainly by hydrolysis of ester bonds generating low molecular fragments
  • After 16 months degradation of virtually all material is observed
           

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